PaHa_c247g00120

Functional evidence

eggNOG

Preferred name: HST2 | Seed ortholog: 329884.A0A4U0WFL1 | COG: S | eggNOG OG: SIR2@131567|n-9, SIR2@2759|DN-16!, SIR2@4751|Bge-31

Gene Ontology

GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000183 rDNA heterochromatin formation; GO:0000792 heterochromatin; GO:0003682 chromatin binding; GO:0003950 NAD+ poly-ADP-ribosyltransferase activity; GO:0004407 histone deacetylase activity; GO:0005515 protein binding; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005677 chromatin silencing complex; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005743 mitochondrial inner membrane; GO:0005759 mitochondrial matrix; GO:0005813 centrosome; GO:0005814 centriole; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005886 plasma membrane; GO:0006281 DNA repair; GO:0006325 chromatin organization; GO:0006476 protein deacetylation; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006633 fatty acid biosynthetic process; GO:0007084 mitotic nuclear membrane reassembly; GO:0007096 regulation of exit from mitosis; GO:0008053 mitochondrial fusion; GO:0008270 zinc ion binding; GO:0008340 determination of adult lifespan; GO:0009060 aerobic respiration; GO:0010507 negative regulation of autophagy; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010801 negative regulation of peptidyl-threonine phosphorylation; GO:0016020 membrane; GO:0016042 lipid catabolic process; GO:0016525 negative regulation of angiogenesis; GO:0017136 histone deacetylase activity, NAD-dependent; GO:0019899 enzyme binding; GO:0021762 substantia nigra development; GO:0022011 myelination in peripheral nervous system; GO:0030097 hemopoiesis; GO:0030496 midbody; GO:0031149 sorocarp stalk cell differentiation; GO:0031507 heterochromatin formation; GO:0031509 subtelomeric heterochromatin formation; GO:0031641 regulation of myelination; GO:0031981 nuclear lumen; GO:0032024 positive regulation of insulin secretion; GO:0032041 histone H3K14 deacetylase activity, NAD-dependent; GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032991 protein-containing complex; GO:0033010 paranodal junction; GO:0033270 paranode region of axon; GO:0033554 cellular response to stress; GO:0033558 protein lysine deacetylase activity; GO:0034599 cellular response to oxidative stress; GO:0034979 NAD-dependent protein lysine deacetylase activity; GO:0034983 peptidyl-lysine deacetylation; GO:0035035 histone acetyltransferase binding; GO:0035748 myelin sheath abaxonal region; GO:0036166 phenotypic switching; GO:0036269 swimming behavior; GO:0040029 epigenetic regulation of gene expression; GO:0042113 B cell activation; GO:0042116 macrophage activation; GO:0042177 negative regulation of protein catabolic process; GO:0042220 response to cocaine; GO:0042325 regulation of phosphorylation; GO:0042594 response to starvation; GO:0042826 histone deacetylase binding; GO:0042903 tubulin deacetylase activity; GO:0043066 negative regulation of apoptotic process; GO:0043130 ubiquitin binding; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043204 perikaryon; GO:0043209 myelin sheath; GO:0043219 lateral loop; GO:0043220 Schmidt-Lanterman incisure; GO:0043388 positive regulation of DNA binding; GO:0043565 sequence-specific DNA binding; GO:0044224 juxtaparanode region of axon; GO:0044671 sorocarp spore cell differentiation; GO:0045598 regulation of fat cell differentiation; GO:0045599 negative regulation of fat cell differentiation; GO:0045717 negative regulation of fatty acid biosynthetic process; GO:0045723 positive regulation of fatty acid biosynthetic process; GO:0045836 positive regulation of meiotic nuclear division; GO:0045843 negative regulation of striated muscle tissue development; GO:0045892 negative regulation of DNA-templated transcription; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0045950 negative regulation of mitotic recombination; GO:0046970 histone H4K16 deacetylase activity, NAD-dependent; GO:0048471 perinuclear region of cytoplasm; GO:0048715 negative regulation of oligodendrocyte differentiation; GO:0051726 regulation of cell cycle; GO:0051775 response to redox state; GO:0051781 positive regulation of cell division; GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore; GO:0052167 symbiont-mediated perturbation of host innate immune response; GO:0060271 cilium assembly; GO:0061433 cellular response to caloric restriction; GO:0061909 autophagosome-lysosome fusion; GO:0070373 negative regulation of ERK1 and ERK2 cascade; GO:0070403 NAD+ binding; GO:0070446 negative regulation of oligodendrocyte progenitor proliferation; GO:0071456 cellular response to hypoxia; GO:0071872 cellular response to epinephrine stimulus; GO:0072686 mitotic spindle; GO:0072687 meiotic spindle; GO:0090042 tubulin deacetylation; GO:0090043 regulation of tubulin deacetylation; GO:0097386 glial cell projection; GO:0097456 terminal loop; GO:0098978 glutamatergic synapse; GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization; GO:0140219 histone methacryllysine demethacrylase activity; GO:0140228 histone benzoyllysine debenzoylase activity; GO:0140297 DNA-binding transcription factor binding; GO:0140773 NAD-dependent protein demyristoylase activity; GO:0140774 NAD-dependent protein depalmitoylase activity; GO:0141208 NAD-dependent protein lysine delactylase activity; GO:1900119 positive regulation of execution phase of apoptosis; GO:1900195 positive regulation of oocyte maturation; GO:1900226 negative regulation of NLRP3 inflammasome complex assembly; GO:1901671 positive regulation of superoxide dismutase activity; GO:1902553 positive regulation of catalase activity; GO:1902725 negative regulation of satellite cell differentiation; GO:1903109 positive regulation of mitochondrial transcription; GO:1903862 positive regulation of oxidative phosphorylation; GO:2000304 positive regulation of ceramide biosynthetic process; GO:2000378 negative regulation of reactive oxygen species metabolic process; GO:2000757 negative regulation of peptidyl-lysine acetylation

KEGG

EC: ec:2.3.1.286 | KO: K11121 | Pathway: 00760, 01100 | Module: M00004, M00006 | BRITE: 00001, 01000, 03032, 03036