Chr04.g34354

Functional evidence

eggNOG

4432.XP_010278318.1,H,[Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives]

Gene Ontology

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives | GO:0001505//regulation of neurotransmitter levels; GO:0006082//organic acid metabolic process; GO:0006464//cellular protein modification process; GO:0006520//cellular amino acid metabolic process; GO:0006544//glycine metabolic process; GO:0006546//glycine catabolic process; GO:0006629//lipid metabolic process; GO:0006631//fatty acid metabolic process; GO:0006633//fatty acid biosynthetic process; GO:0006732//coenzyme metabolic process; GO:0006790//sulfur compound metabolic process; GO:0006807//nitrogen compound metabolic process; GO:0008150//biological_process; GO:0008152//metabolic process; GO:0008610//lipid biosynthetic process; GO:0009056//catabolic process; GO:0009058//biosynthetic process; GO:0009063//cellular amino acid catabolic process; GO:0009069//serine family amino acid metabolic process; GO:0009071//serine family amino acid catabolic process; GO:0009106//lipoate metabolic process; GO:0009107//lipoate biosynthetic process; GO:0009108//coenzyme biosynthetic process; GO:0009249//protein lipoylation; GO:0009987//cellular process; GO:0010467//gene expression; GO:0016053//organic acid biosynthetic process; GO:0016054//organic acid catabolic process; GO:0017144//drug metabolic process; GO:0018065//protein-cofactor linkage; GO:0018130//heterocycle biosynthetic process; GO:0018193//peptidyl-amino acid modification; GO:0018205//peptidyl-lysine modification; GO:0019538//protein metabolic process; GO:0019752//carboxylic acid metabolic process; GO:0032787//monocarboxylic acid metabolic process; GO:0036211//protein modification process; GO:0042133//neurotransmitter metabolic process; GO:0042135//neurotransmitter catabolic process; GO:0042737//drug catabolic process; GO:0043170//macromolecule metabolic process; GO:0043412//macromolecule modification; GO:0043436//oxoacid metabolic process; GO:0044237//cellular metabolic process; GO:0044238//primary metabolic process; GO:0044248//cellular catabolic process; GO:0044249//cellular biosynthetic process; GO:0044255//cellular lipid metabolic process; GO:0044260//cellular macromolecule metabolic process; GO:0044267//cellular protein metabolic process; GO:0044272//sulfur compound biosynthetic process; GO:0044281//small molecule metabolic process; GO:0044282//small molecule catabolic process; GO:0044283//small molecule biosynthetic process; GO:0046394//carboxylic acid biosynthetic process; GO:0046395//carboxylic acid catabolic process; GO:0046483//heterocycle metabolic process; GO:0051186//cofactor metabolic process; GO:0051188//cofactor biosynthetic process; GO:0051604//protein maturation; GO:0065007//biological regulation; GO:0065008//regulation of biological quality; GO:0071704//organic substance metabolic process; GO:0072330//monocarboxylic acid biosynthetic process; GO:1901360//organic cyclic compound metabolic process; GO:1901362//organic cyclic compound biosynthetic process; GO:1901564//organonitrogen compound metabolic process; GO:1901565//organonitrogen compound catabolic process; GO:1901575//organic substance catabolic process; GO:1901576//organic substance biosynthetic process; GO:1901605//alpha-amino acid metabolic process; GO:1901606//alpha-amino acid catabolic process | GO:0005575//cellular_component; GO:0005622//intracellular; GO:0005623//cell; GO:0005737//cytoplasm; GO:0005739//mitochondrion; GO:0005759//mitochondrial matrix; GO:0031974//membrane-enclosed lumen; GO:0043226//organelle; GO:0043227//membrane-bounded organelle; GO:0043229//intracellular organelle; GO:0043231//intracellular membrane-bounded organelle; GO:0043233//organelle lumen; GO:0044422//organelle part; GO:0044424//intracellular part; GO:0044429//mitochondrial part; GO:0044444//cytoplasmic part; GO:0044446//intracellular organelle part; GO:0044464//cell part; GO:0070013//intracellular organelle lumen | GO:0003674//molecular_function; GO:0003824//catalytic activity; GO:0016740//transferase activity; GO:0016782//transferase activity, transferring sulfur-containing groups; GO:0016783//sulfurtransferase activity; GO:0016992//lipoate synthase activity; GO:0070283//radical SAM enzyme activity

KEGG

K03644 | lipA

NR

RWR90726.1 lipoyl synthase 2, mitochondrial [Cinnamomum micranthum f. kanehirae]

Swiss-Prot

A5CB81.1 RecName: Full=Lipoyl synthase, mitochondrial; AltName: Full=Lipoate synthase; Short=LS; Short=Lip-syn; AltName: Full=Lipoic acid synthase [Vitis vinifera]